Paper / report

A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

A Cee® Apogee® coater was used to prepare the electron-beam resist stack for silicon nanopillar arrays in a digital SERS biosensing platform. The research applies these arrays to single-cytokine counting and monitoring immune toxicities during immunotherapy.

How Cee® equipment is used

The pillar arrays were fabricated on 4-inch silicon wafers. Two PMMA layers, 495K A4 beneath 950K A4, were each spin coated at 1500 rpm for 60 seconds using the named Cee® Apogee® coater. Electron-beam lithography defined the pillar pattern. The methods identify the Apogee® family but do not specify a 200 or 450 model. Source: Methods, Fabrication of pillar arrays.

Equipment reported
Apogee® Spin Coater; model size not reported
Source type
Research paper
Publication year
2021
Materials
PMMA
Substrate
Si
Source
Nature Communications (Springer Nature)

Process context

The process details describe the cited work. Reported recipes and results depend on the authors’ materials, substrates, and equipment configuration. Materials recorded for this reference include PMMA.

Source and equipment evidence

Nature Communications (Springer Nature). 2021. A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy.

Open original source ↗

Application summary prepared by Cee. The original source remains the authority for its methods and findings.

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